Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2384H3735N603O702S17

DescriptionStandard

        MLSLLILLLNLTNHAFGQNPAIKAILTNKGLQYASHIGADWMQEKIGSMIIPDVRGGVHIGIGTVNYVLDGISVSGCDVPEPSVEFYEGVGLKAVISGLSISFTGNWHTRFGIITDGGSFDLAVFNVDVASVVQIGSDCSGHISISSENCDAKIDEASINFHGGASLIFQPFVTLFHNRIKAIIEERICPVVEEHVTDLERHLAEMQVSFKVNSALVLDVPLTNSPLVDSISLGLDLKGEFYSVQSHTDPPFKAEPFNLPEDNDHMLSLGLSEFTVNSASYAYFSAGLLQAQINDSMIPKTSPFRLNTTSFGPLIPQLPKLFPNMLMELQVYARDVPMFSFQADKVTLKFPGAVKAFAIQPNASWTPLFKLNVDSIFSGVIRISEEKLKGLMELSNFTLTLASSEVGIFQTAALENFMKLGMKISVLGKLNAKLEEGIVLPTMHHIHLVNPALKIQEGFVSIASDLDVKSGERESTSEAIYPY
    

Molecular Weight52620.88 Da

Isoelectric Point (pI)5.12

Net Charge (pH 7.0)-18.25

Net Charge (pH 7.4) -19.34

Charge Density (pH 7.0) -0.0378

GRAVY Index0.20

Hydrophobic Moment 0.66

Boman Index0.19

Instability Index31.90

Aliphatic Index 103.13

Aromaticity 0.0849

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0009202 VERIFIED: NO

Provenance & Taxonomy

OrganismHucho hucho [Bacterium]

FamilyBPI

Tax ID62062

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence