Peptide Database

Peptide NameNigrocin-2JDb

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC93H162N24O23S3

DescriptionStandard

        GIFGKILGVGKKVLCGLSGMC
    

Molecular Weight2080.62 Da

Isoelectric Point (pI)9.39

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.50

Charge Density (pH 7.0) 0.1303

GRAVY Index1.12

Hydrophobic Moment 0.52

Boman Index0.41

Instability Index-5.56

Aliphatic Index 120.48

Aromaticity 0.0476

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 743.61

LogP -5.34

H-bond Donors 28.0

H-bond Acceptors 29.0

Rotatable Bonds 73.0

Heavy Atoms 143.0

Ring Count 1.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0265694 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana jingdongensis [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0304861 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana jingdongensis [Animal]

FamilyNigrocin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans

Activity64 μg/mL

MethodMIC

RECORD: Rec_0340838 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana jingdongensis [Animal]

FamilyNigrocin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide15-21

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetEscherichia coli ATCC 25992

Activity8 μM

MethodMIC

RECORD: Rec_0346258 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 0.0%, T 57.1%, C 42.9% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative

RECORD: Rec_0383875 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct based on Odorrana jingdongensis [Synthetic]

FamilyNigrocin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide15-21

Bio-Activity Profile

Function

Antimicrobial Antifungal

TargetStaphylococcus aureus

Activity8 μM

MethodMIC

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