Peptide Database

Peptide NamePea-FMRFa-21

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length8 amino acids

Chemical FormulaC45H75N15O13

DescriptionStandard

        TDRNFIRL
    

Molecular Weight1034.17 Da

Isoelectric Point (pI)9.26

Net Charge (pH 7.0)0.40

Net Charge (pH 7.4) 0.21

Charge Density (pH 7.0) 0.0499

GRAVY Index-0.70

Hydrophobic Moment 0.74

Boman Index-0.40

Instability Index-4.04

Aliphatic Index 97.50

Aromaticity 0.1250

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 491.44

LogP -4.62

H-bond Donors 18.0

H-bond Acceptors 14.0

Rotatable Bonds 34.0

Heavy Atoms 73.0

Ring Count 1.0

Amide Bonds 8.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0054616 VERIFIED: YES

Provenance & Taxonomy

OrganismPeriplaneta americana [Animal]

FamilyPea-FMRFa

Tax ID6978

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Neuromodulator ACE inhibitory

Half-LifeMammalian: 7.2 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0113394 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0275577 VERIFIED: YES

Provenance & Taxonomy

OrganismPeriplaneta americana [Animal]

FamilyFMRFamide related peptide

Tax ID6978

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator