Peptide Database

Peptide NamePalifermin

Function Ontology

Regulatory peptide ▸ Cell signaling / Growth factor signaling ▸ Growth factor activity

Standard StatusStandard

Sequence Length140 amino acids

Chemical FormulaC724H1147N203O206S9

DescriptionStandard

        SYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
    

Molecular Weight16279.67 Da

Isoelectric Point (pI)9.47

Net Charge (pH 7.0)8.71

Net Charge (pH 7.4) 8.24

Charge Density (pH 7.0) 0.0622

GRAVY Index-0.65

Hydrophobic Moment 0.57

Boman Index-0.12

Instability Index36.43

Aliphatic Index 70.36

Aromaticity 0.1071

Extinction Coeff. Reduced 22920.00

Extinction Coeff. Oxidized 23045.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6730.23

LogP -60.18

H-bond Donors 237.0

H-bond Acceptors 227.0

Rotatable Bonds 563.0

Heavy Atoms 1142.0

Ring Count 22.0

Amide Bonds 153.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296380 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Escherichia coli [Bacterium]

FamilyPeptide/protein therapeutic

Tax ID9606;562

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Growth factor Epithelial protective

PaperPubMed-linked source references: PMID:25270293; PMID:16179960; PMID:28234746; PMID:28093295; PMID:27942550; PMID:27090960; PMID:27034762; PMID:26968792; PMID:26862696 PMID25270293;16179960;28234746;28093295;27942550;27090960;27034762;26968792;26862696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270293/