Peptide Database

Peptide NamePhoratoxins E

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC198H325N65O64S6

DescriptionStandard

        KSCCPTTTARNIYNTCRFGGGSRPVCAKLSGCKIISGTKCDSGHDH
    

Molecular Weight4832.49 Da

Isoelectric Point (pI)9.13

Net Charge (pH 7.0)4.87

Net Charge (pH 7.4) 4.47

Charge Density (pH 7.0) 0.1059

GRAVY Index-0.46

Hydrophobic Moment 0.64

Boman Index-0.11

Instability Index52.21

Aliphatic Index 44.57

Aromaticity 0.0435

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2085.69

LogP -31.53

H-bond Donors 81.0

H-bond Acceptors 77.0

Rotatable Bonds 158.0

Heavy Atoms 333.0

Ring Count 6.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0023428 VERIFIED: YES

Provenance & Taxonomy

OrganismPhoradendron tomentosum [Plant]

FamilyThionin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidemultiple disulfide bonds reported, sites not specified

Bio-Activity Profile

Function

Anticancer Cytotoxic

Target10 cancer cell lines