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MYP_024652
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Basic Information
Latarcin 2a
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxin
Standard
26 amino acids
C136H229N41O29
Standard
Sequence
GLFGKLIKKFGRKAISYAVKKARGKH
Physicochemical Analysis
2902.53 Da
11.33
8.84
8.57
0.3400
-0.44
0.90
-0.14
1.29
82.69
0.1154
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1165.90
-8.23
43.0
39.0
105.0
206.0
4.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0052329 VERIFIED: YES
Provenance & Taxonomy
Lachesana tarabaevi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Pseudomonas aeruginosa PAO1
6.7 μM
MIC
PMID16735513;16939228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16735513/
RECORD: Rec_0054110 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Cytotoxic
Human erythrocytes
6 μM
EC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/19563807/ PMID19563807 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19563807/
RECORD: Rec_0057293 VERIFIED: YES
Provenance & Taxonomy
Lachesana tarabaevi [Animal]
Latarcin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
yeasts P. pastoris
6.7 μM
MIC
PaperLatarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity. PMID16735513 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16735513/
RECORD: Rec_0068731 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Rabbit erythrocytes
6 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/16735513/ PMID16735513 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16735513/
RECORD: Rec_0100295 VERIFIED: YES
Provenance & Taxonomy
Lachesana tarabaevi [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
rabbit erythrocytes
PMID16735513;16939228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16735513/
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