Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length482 amino acids

Chemical FormulaC2444H3786N608O704S15

DescriptionStandard

        MHAKTIPVLWGCFFLWNLGISSSQTTYPGIKARATQRALDYAVQAGMEMIEQMVKERNIPNINGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISTNWEIKSPLLCGGADLFLSAIYFTGFHAHVSFSGELSVLYNSFAEPMEKPILKNINEMLCPIITGEVEALNANLSALEVLTKIDNYTLLDYSLIDSPEVTENYLDLNLKGVFYPLENLADPPFSPVPFVLPEGSDSMLYIGISEYFFKSASFAYFSAGAFNVTLSTKEISNYFVQNSQGFGNVLSRLAEIYILSQPFMVQIMATEPPVISLRPGNFTLDIPASIIMLTQPRNSTVETIVSMDFVASTSVGLVILGQRLICSLSLNRFRLSLPEPNRSNIEVLKFENILSSILHFGVLPLANAKLQQGFPLPNPHKISLVNSDIEVLEGFLLISTDLKYETSSKRQPSFHGWEGLNLISRQWRGKPAP
    

Molecular Weight53430.83 Da

Isoelectric Point (pI)5.31

Net Charge (pH 7.0)-9.87

Net Charge (pH 7.4) -10.61

Charge Density (pH 7.0) -0.0205

GRAVY Index0.14

Hydrophobic Moment 0.72

Boman Index0.18

Instability Index42.02

Aliphatic Index 101.14

Aromaticity 0.1079

Extinction Coeff. Reduced 51340.00

Extinction Coeff. Oxidized 51590.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0345366 VERIFIED: NO

Provenance & Taxonomy

OrganismMicrocebus murinus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence