Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length48 amino acids

Chemical FormulaC221H360N60O75S5

DescriptionStandard

        MKNSKDVLNNAIEEVSEKELMEVAGGKRGTGWIATITDDCPNSIFVCC
    

Molecular Weight5217.90 Da

Isoelectric Point (pI)4.55

Net Charge (pH 7.0)-3.52

Net Charge (pH 7.4) -3.79

Charge Density (pH 7.0) -0.0732

GRAVY Index-0.18

Hydrophobic Moment 0.56

Boman Index0.03

Instability Index38.62

Aliphatic Index 79.17

Aromaticity 0.0417

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2196.14

LogP -24.41

H-bond Donors 77.0

H-bond Acceptors 77.0

Rotatable Bonds 178.0

Heavy Atoms 361.0

Ring Count 4.0

Amide Bonds 51.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0338674 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus pseudoporcinus [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence