Peptide Database

Peptide NamePurotoxin-2

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length64 amino acids

Chemical FormulaC308H488N88O97S9

DescriptionStandard

        AKACTPLLHDCSHDRHSCCRGDMFKYVCDCFYPEGEDKTEVCSCQQPKSHKIAEKIIDKAKTTL
    

Molecular Weight7264.29 Da

Isoelectric Point (pI)7.05

Net Charge (pH 7.0)0.07

Net Charge (pH 7.4) -0.46

Charge Density (pH 7.0) 0.0011

GRAVY Index-0.64

Hydrophobic Moment 0.69

Boman Index-0.16

Instability Index50.97

Aliphatic Index 51.88

Aromaticity 0.0625

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2978.41

LogP -32.28

H-bond Donors 110.0

H-bond Acceptors 110.0

Rotatable Bonds 243.0

Heavy Atoms 502.0

Ring Count 11.0

Amide Bonds 65.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0304708 VERIFIED: NO

Provenance & Taxonomy

OrganismGeolycosa sp. [Animal]

Familyspider toxin CSTX superfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Disulfide4-19; 11-28; 18-44; 30-42

Bio-Activity Profile

Function

Toxin Venom spider toxin CSTX superfamily

RECORD: Rec_0432812 VERIFIED: YES

Provenance & Taxonomy

OrganismGeolycosa sp. [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Toxin Venom P2X3 receptor modulator

Targethuman P2X3 receptor (CHO cells); murine P2X3 receptor (CHO cells)

Activity3-4 fold IC50 decrease

MethodElectrophysiology; P2X3 high-affinity desensitization assay (PT2 50 nM)