Peptide Database

Peptide NameT1562(FIV envelope protein (724-758))

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC194H288N50O59S

DescriptionStandard

        IWNHGNITLGEWYNQTKDLQQKFYEIIMDIEQNNV
    

Molecular Weight4296.73 Da

Isoelectric Point (pI)4.50

Net Charge (pH 7.0)-3.15

Net Charge (pH 7.4) -3.41

Charge Density (pH 7.0) -0.0899

GRAVY Index-0.79

Hydrophobic Moment 0.59

Boman Index0.01

Instability Index57.34

Aliphatic Index 86.29

Aromaticity 0.1429

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1820.25

LogP -14.57

H-bond Donors 59.0

H-bond Acceptors 58.0

Rotatable Bonds 144.0

Heavy Atoms 304.0

Ring Count 8.0

Amide Bonds 43.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0404582 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-FIV Fusion inhibition

TargetFeline immunodeficiency virus (FIV) | FIV/CrFK cells; HeLa cells

Activity0.318 μM

MethodEC50

Half-LifeMammalian: 20 h; Yeast: 30 min; E. coli: >10 h

PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/

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