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MYP_024537
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Basic Information
T1562(FIV envelope protein (724-758))
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-Lentivirus ▸ Anti-FIV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
35 amino acids
C194H288N50O59S
Standard
Sequence
IWNHGNITLGEWYNQTKDLQQKFYEIIMDIEQNNV
Physicochemical Analysis
4296.73 Da
4.50
-3.15
-3.41
-0.0899
-0.79
0.59
0.01
57.34
86.29
0.1429
13980.00
13980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1820.25
-14.57
59.0
58.0
144.0
304.0
8.0
43.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018283 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0159883 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Feline immunodeficiency virus (FIV)
PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0163208 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Feline immunodeficiency virus (FIV)
1.236 μM
IC90
PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0312578 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Feline immunodeficiency virus (FIV):inhibition of cell-cell fusion between FIV/CrFK cells and HeLa cells
0.318 μM
EC50
PaperPubMed PMID: 12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
RECORD: Rec_0373283 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-FIV Fusion inhibition
Feline immunodeficiency virus (FIV) | FIV/CrFK cells; HeLa cells
1.236 μM
EC90
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperC-Terminal gp40 peptide analogs inhibit feline immunodeficiency virus: cell fusion and virus spread. | Medinas RJ, Lambert DM, Tompkins WA. | J Virol. 2002 Sep;76(18):9079-86. | DOI:10.1128/jvi.76.18.9079-9086.2002 | PMID:12186891 PMID12186891 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12186891/
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