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MYP_024528
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Basic Information
Indolocidin-ac
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
13 amino acids
C100H131N25O14
Standard
Sequence
ILPWKWPWWPWRR
Physicochemical Analysis
1907.27 Da
12.00
2.76
2.55
0.2122
-1.07
0.45
0.02
76.28
60.00
0.3846
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
614.92
4.10
23.0
17.0
48.0
139.0
13.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0173735 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin/indolicidin
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Immunomodulatory
Escherichia coli
PaperIndolicidin, a novel bactericidal tridecapeptide amide from neutrophils | Requirements for antibacterial and hemolytic activities in the bovine neutrophil derived 13-residue peptide indolicidin PMID15378218;849687 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15378218/
RECORD: Rec_0182933 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
10 μg/mL
MIC
PMID1537821;19191872;35254120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1537821/
RECORD: Rec_0183830 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral Anti-Gram-negative
Escherichia coli
200 μg/mL
MIC
PaperThe effects of tryptophan and hydrophobicity on the structure and bioactivity of novel indolicidin derivatives with promising pharmaceutical potential. PMID20237682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20237682/
RECORD: Rec_0189337 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer Wound healing
Pseudomonas aeruginosa ATCC-27853 or NCDC-0105
12.5-25 μM
MIC
PaperIndolicidin, a novel bactericidal tridecapeptide amide from neutraphils
RECORD: Rec_0199464 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin/indolicidin
9913.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Immunomodulatory
Staphylococcus aureus
PaperIndolicidin, a novel bactericidal tridecapeptide amide from neutrophils | Requirements for antibacterial and hemolytic activities in the bovine neutrophil derived 13-residue peptide indolicidin PMID15378218;849687 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15378218/
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