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MYP_024528
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Basic Information
Indolocidin-ac
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
13 amino acids
C100H131N25O14
Standard
Sequence
ILPWKWPWWPWRR
Physicochemical Analysis
1907.27 Da
12.00
2.76
2.55
0.2122
-1.07
0.45
0.02
76.28
60.00
0.3846
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
614.92
4.10
23.0
17.0
48.0
139.0
13.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0144242 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HSV Replication inhibition
Herpes simplex virus type 1 (HSV-1) | Vero cells
28.68 μM
EC50
Mammalian: 20 h; Yeast: 30 min; E. coli: >10 h
PaperAntiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. | Albiol Matanic VC, Castilla V. | Int J Antimicrob Agents. 2004 Apr;23(4):382-9. | DOI:10.1016/j.ijantimicag.2003.07.022 | PMID:15081088 PMID15081088 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15081088/
RECORD: Rec_0148747 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Indolicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human erythrocytes
200 μg/mL
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/12207877/ PMID12207877 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12207877/
RECORD: Rec_0152848 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 0.0%, E 0.0%, T 23.1%, C 76.9% [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0157973 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
Pseudomonas aeruginosa
PMID19455552 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19455552/
RECORD: Rec_0159684 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
allo-residue reported
Bio-Activity Profile
Antimicrobial Antifungal Antiviral Anticancer Wound healing
A. johnsonii NCDC-0072
6 μM
MIC
PaperIndolicidin, a novel bactericidal tridecapeptide amide from neutraphils
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