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MYP_024528
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Basic Information
Indolocidin-ac
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Wound healing/Regeneration ▸ Wound healing
Standard
13 amino acids
C100H131N25O14
Standard
Sequence
ILPWKWPWWPWRR
Physicochemical Analysis
1907.27 Da
12.00
2.76
2.55
0.2122
-1.07
0.45
0.02
76.28
60.00
0.3846
27500.00
27500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
614.92
4.10
23.0
17.0
48.0
139.0
13.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0222252 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
PaperSelsted M. E., Novotny M. J ., Morris W. L., Tang Y.-Q., Smith W., Cullor J. S.. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J. Biol. Chem. 267, 4292-4295, 1992.
RECORD: Rec_0224538 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Indolicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Rat erythrocytes
10 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/8849687/ PMID8849687 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8849687/
RECORD: Rec_0228341 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Cathelicidin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
hRBC
200 μg/mL
Hemolysis
PMID1537821;19191872;35254120 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1537821/
RECORD: Rec_0228837 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Indolicidin
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP37294
RECORD: Rec_0231539 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
Salmonella typhimurium
PMID19455552 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19455552/
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