Peptide Database

Peptide NameUnnamed

Function Ontology

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length7 amino acids

Chemical FormulaC46H58N12O11

DescriptionStandard

        EWFNGRF
    

Molecular Weight955.03 Da

Isoelectric Point (pI)6.10

Net Charge (pH 7.0)-0.16

Net Charge (pH 7.4) -0.33

Charge Density (pH 7.0) -0.0233

GRAVY Index-1.03

Hydrophobic Moment 0.21

Boman Index-0.05

Instability Index-34.37

Aliphatic Index 0.00

Aromaticity 0.4286

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 396.00

LogP -1.85

H-bond Donors 14.0

H-bond Acceptors 11.0

Rotatable Bonds 28.0

Heavy Atoms 69.0

Ring Count 4.0

Amide Bonds 7.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0037658 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0306175 VERIFIED: NO

Provenance & Taxonomy

OrganismHydra vulgaris [Animal]

FamilyHydra-RFamide

Tax ID6087

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamylation

C-TermAmidation

Other ModsN-terminal pyroglutamylation

Bio-Activity Profile

Function

Neuropeptide RFamide

Half-LifeMammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour

RECORD: Rec_0417876 VERIFIED: YES

Provenance & Taxonomy

OrganismHydra vulgaris [Animal]

FamilyFMRFamide related peptide

Tax ID6087

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamylation

C-TermAmidation

Other ModsN-terminal pyroglutamylation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator Ion channel agonist

TargetHyNaC2/3/5 peptide-gated ion channel

Activity0.35 μM

MethodEC50; two-electrode voltage-clamp in Xenopus oocytes

RECORD: Rec_0432809 VERIFIED: YES

Provenance & Taxonomy

OrganismHydra vulgaris [Animal]

FamilyFMRFamide related peptide

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermPyroglutamylation

C-TermAmidation

Other ModsN-terminal pyroglutamylation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator Ion channel agonist

TargetHyNaC2/3 peptide-gated ion channel

Activity33 μM

MethodEC50; two-electrode voltage-clamp in Xenopus oocytes