Peptide Database

Peptide NameSLAY-screened peptide P3336

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC91H160N36O26S3

DescriptionStandard

        CAGSHILGTRSPRRCCRGLIN
    

Molecular Weight2270.66 Da

Isoelectric Point (pI)10.44

Net Charge (pH 7.0)3.82

Net Charge (pH 7.4) 3.52

Charge Density (pH 7.0) 0.1818

GRAVY Index-0.19

Hydrophobic Moment 0.88

Boman Index-0.18

Instability Index97.07

Aliphatic Index 79.05

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1016.59

LogP -14.25

H-bond Donors 41.0

H-bond Acceptors 34.0

Rotatable Bonds 74.0

Heavy Atoms 156.0

Ring Count 2.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0278628 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/