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MYP_024378
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Basic Information
Theromacin (Arthropods, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
75 amino acids
C353H544N112O111S10
Standard
Sequence
GCFEDWSRCSPSTASATGVLWRSCDSYCKVCFKADRGECYDSPSLNCPHRLPNNKQCRCINARTAKDNRNPTCWA
Physicochemical Analysis
8453.43 Da
8.60
3.75
3.34
0.0500
-0.76
0.57
-0.22
65.87
36.53
0.0933
19480.00
20105.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3632.15
-48.43
138.0
126.0
267.0
586.0
16.0
81.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027464 VERIFIED: YES
Provenance & Taxonomy
Hirudo medicinalis [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus megaterium ATCC 14581
0.2-0.39 μg/mL
MBC
PaperPubMed PMID: 22396551 PMID22396551 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22396551/
RECORD: Rec_0125984 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US8173768B2/en PatentUS 8173768 B2
RECORD: Rec_0137713 VERIFIED: YES
Provenance & Taxonomy
Hirudo medicinalis [Animal]
macin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
2-9; 24-28; 31-73; 39-47; 57-59
Bio-Activity Profile
Antimicrobial macin family Host defense
PaperPDB 2LN8 structural record; NMR; chain A; residues 1-75
RECORD: Rec_0251870 VERIFIED: YES
Provenance & Taxonomy
Hirudo medicinalis [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 12600 (LD90=25 μg/ml)
PaperPubMed PMID: 22396551 PMID22396551 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22396551/
RECORD: Rec_0256718 VERIFIED: NO
Provenance & Taxonomy
Hirudo medicinalis [Animal]
Macin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ1977
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