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MYP_024362
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Basic Information
HCV gp (548562), E2-42
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C77H101N19O22S2
Standard
Sequence
QGSWFGCTWMNSTGF
Physicochemical Analysis
1708.87 Da
5.52
-0.25
-0.47
-0.0167
-0.20
0.21
0.29
31.17
0.00
0.2667
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
669.40
-7.42
25.0
24.0
50.0
120.0
6.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0048185 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Human hepatocellular carcinoma Huh7.5/CD81
>0.1 μM
Cytotoxicity
PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
RECORD: Rec_0064077 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV Entry inhibition
HCV (Hepatitis C virus) | Huh7.5/CD81 cells
0.001-0.005 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperA screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2. | Yin P, Zhang L, Ye F, Deng Y, Lu S, Li YP, Zhang L, Tan W. | A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2. | DOI:10.1038/s41598-017-04274-8 | PMID:28638089 PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
RECORD: Rec_0068666 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
5/CD81 cells
0.001 μM
IC50
PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
RECORD: Rec_0141619 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus (HCV)
PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
RECORD: Rec_0182510 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID28638089 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28638089/
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