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MYP_024351
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Basic Information
Class I defensin, NaD2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
47 amino acids
C212H338N76O66S8
Standard
Sequence
RTCESQSHRFKGPCARDSNCATVCLTEGFSGGDCRGFRRRCFCTRPC
Physicochemical Analysis
5263.94 Da
8.99
4.77
4.40
0.1016
-0.69
0.56
-0.32
67.03
18.72
0.0851
0.00
500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2331.46
-34.47
94.0
80.0
171.0
362.0
7.0
48.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0138271 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Cytotoxic
Human histiocytic lymphoma U-937
PMID27503651;24015960 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27503651/
RECORD: Rec_0145767 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
U-937
5.9±1.3 %
Cytotoxicity
PaperPubMed PMID: 27503651 PMID27503651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27503651/
RECORD: Rec_0157648 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antifungal Anticancer Cytotoxic
Fusarium graminearum
2 μM
IC50
PMID27503651;24015960 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27503651/
RECORD: Rec_0182086 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Fusarium oxysporum f.sp. vasinfectum
8.3
IC50
PMID24015961;27503651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24015961/
RECORD: Rec_0206424 VERIFIED: YES
Provenance & Taxonomy
Nicotiana alata [Plant]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Aspergillus nidulans
5 μM
IC50
PMID24015961;27503651 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24015961/
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