MYP_024349
Accutin
Hemostasis
▸
Antithrombotic activity
Standard
43 amino acids
C192H289N59O65S7
Standard
GAQCTAGPCCWPCEGTICRRARGDDLDDYCNGISADCPRNPYY
4688.16 Da
4.46
-2.30
-2.62
-0.0536
-0.64
0.49
-0.12
25.34
36.51
0.0930
9970.00
10345.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1988.20
-25.70
75.0
70.0
141.0
323.0
9.0
45.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0281396
VERIFIED: YES
Provenance & Taxonomy
Agkistrodon acutus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antithrombotic
Antiplatelet
Platelet aggregation inhibitor
Integrin αIIbβ3 antagonist
human platelets; integrin αIIbβ3 (GPIIb/IIIa)
66-267 nM
IC50 (human platelet aggregation inhibition; ADP/collagen/thrombin/U46619)
RECORD: Rec_0432784
VERIFIED: YES
Provenance & Taxonomy
Agkistrodon acutus [Animal]
Disintegrin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiangiogenic
Integrin αvβ3 antagonist
Apoptosis-inducing
human umbilical vein endothelial cells (HUVECs); integrin αvβ3
Integrin αvβ3 binding/adhesion inhibition; Matrigel tube-formation and apoptosis assays