Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length183 amino acids

Chemical FormulaC917H1390N206O278S8

DescriptionStandard

        IDDLAKVDYSLNSLPAVFQPFIDLDLKGIVYPAGNCSGPPYVAAPFTIPDQSDSMLYLAFSEYFFQTSSFAYYTAGAFNITIAEETCSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLMATETPIISLGQDSFTVEIQGSMEVFAVLPDSTPQSLFTTNIAANTSIALNIFDQKLMGSLCLNR
    

Molecular Weight20004.58 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-12.25

Net Charge (pH 7.4) -12.54

Charge Density (pH 7.0) -0.0669

GRAVY Index0.32

Hydrophobic Moment 0.55

Boman Index0.26

Instability Index44.23

Aliphatic Index 92.79

Aromaticity 0.1311

Extinction Coeff. Reduced 14900.00

Extinction Coeff. Oxidized 15025.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7624.89

LogP -81.86

H-bond Donors 258.0

H-bond Acceptors 274.0

Rotatable Bonds 630.0

Heavy Atoms 1409.0

Ring Count 37.0

Amide Bonds 197.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0282988 VERIFIED: NO

Provenance & Taxonomy

OrganismSpheniscus mendiculus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence