Peptide Database

Peptide NamePoca A

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC135H218N36O42S6

DescriptionStandard

        GLPCAESCVFIPCTITAILGCSCRDRVCYD
    

Molecular Weight3209.78 Da

Isoelectric Point (pI)4.78

Net Charge (pH 7.0)-1.29

Net Charge (pH 7.4) -1.59

Charge Density (pH 7.0) -0.0431

GRAVY Index0.77

Hydrophobic Moment 0.38

Boman Index0.20

Instability Index58.41

Aliphatic Index 91.00

Aromaticity 0.0667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1226.49

LogP -12.83

H-bond Donors 49.0

H-bond Acceptors 47.0

Rotatable Bonds 98.0

Heavy Atoms 219.0

Ring Count 4.0

Amide Bonds 29.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0066627 VERIFIED: YES

Provenance & Taxonomy

OrganismPombalia calceolaria [Plant]

FamilyCyclotide

Structure & Mods

Confighead-to-tail cyclic peptide scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

DisulfideCysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family

Bio-Activity Profile

Function

Cytotoxic

TargetMDA-MB-231

Activity1.8 μM

MethodIC50