Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2331H3737N603O672S16

DescriptionStandard

        MFLCGWLVMGMLIPTILSVNPGVEVKLTEKGIEYGRQLGVAAIQEKLKSIRLPDFSGKQRVSPIGKVQYSLTNIQVVNIGLPIAPIQLVAGSGVKLSINGAFINLRGNWRVKYLRWVKNSGSFDLNVNGLSVAETLGIKSDNTGRPEVSSISCGASVGSVKVKFHGGASWLYNLFSRYINRALESALQKQICPLVTNAISDVNPRLKTLNVLANVDKYAEIEYAMVSSPDVSTSSINLKLKGQFYNIGQHQEPPFSAPAFSLPSENSNMLYIGMSAFTVNSAAFVYHKAGALSMYITDDMIPKSSPIRLTTNTFGTFIPEISKQFPGLMMKLLVKTDKSPVVTFEPNSATVQATGTVTAYAIQPDNTLTPLFILNLDTSVSARLFLTGMKLAASLTLNKMNLTVETSYVGEFQVRSLSNVLQLVLKWVVIPTVNVQLGKGYPLPALGKTALENTQLQIQKDYIMIGTDVKFTA
    

Molecular Weight51474.28 Da

Isoelectric Point (pI)9.49

Net Charge (pH 7.0)13.75

Net Charge (pH 7.4) 13.23

Charge Density (pH 7.0) 0.0291

GRAVY Index0.15

Hydrophobic Moment 0.83

Boman Index0.15

Instability Index32.86

Aliphatic Index 103.00

Aromaticity 0.0825

Extinction Coeff. Reduced 49850.00

Extinction Coeff. Oxidized 49975.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0321148 VERIFIED: NO

Provenance & Taxonomy

OrganismTetraodon nigroviridis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence