Peptide Database

Peptide NameNatriuretic peptide NsNP-a

Function Ontology

Antimicrobial

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC157H259N47O53S3

DescriptionStandard

        SGSEVAKIGDGCFGLPLDRIGSASGMGCRSVPKPTPGGS
    

Molecular Weight3749.21 Da

Isoelectric Point (pI)7.78

Net Charge (pH 7.0)0.44

Net Charge (pH 7.4) 0.20

Charge Density (pH 7.0) 0.0114

GRAVY Index-0.12

Hydrophobic Moment 0.47

Boman Index0.10

Instability Index32.95

Aliphatic Index 60.00

Aromaticity 0.0256

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1563.31

LogP -23.15

H-bond Donors 56.0

H-bond Acceptors 57.0

Rotatable Bonds 120.0

Heavy Atoms 260.0

Ring Count 5.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0142194 VERIFIED: NO

Provenance & Taxonomy

OrganismNotechis scutatus scutatus [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0257015 VERIFIED: YES

Provenance & Taxonomy

OrganismNotechis scutatus scutatus [Animal]

Familynatriuretic peptide NsNP

Tax ID70142

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour