Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length302 amino acids

Chemical FormulaC1485H2361N377O430S10

DescriptionStandard

        MVFSSCATFWIRLSWSMLLHAWLLLVALTTLTSGLNPGVKVKLTQKGLEYGRELGIASIQQKLKTIKLPDVTLFGTFINTTVFFLSMHIINVGLPQSAVSLVPGAGIKLSIGNAYLSLNGNWRVKYLKFIKDSGSFDLSVSGLSITTTVAVNSDETGRPTVTGNNCVNSQSDNSVLLLSSWLYNLFKDFIAKALRSALEKQVKQLQLSVLQETSGYAEIQYSLVSSPVISTTSHQEPPFIPNVFSMPPESNNMLYLGLSSYTANSAGFVYTTAGAIARSFIKKGLVTVAGSDAPLLCCRITC
    

Molecular Weight32696.55 Da

Isoelectric Point (pI)9.25

Net Charge (pH 7.0)7.72

Net Charge (pH 7.4) 7.22

Charge Density (pH 7.0) 0.0256

GRAVY Index0.31

Hydrophobic Moment 0.69

Boman Index0.20

Instability Index32.17

Aliphatic Index 105.53

Aromaticity 0.0927

Extinction Coeff. Reduced 40910.00

Extinction Coeff. Oxidized 41160.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0047179 VERIFIED: NO

Provenance & Taxonomy

OrganismPeriophthalmus magnuspinnatus [Bacterium]

FamilyBPI

Tax ID409849

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence