Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length165 amino acids

Chemical FormulaC834H1333N223O220S8

DescriptionStandard

        PTDLPMAHKPMLLLAVTEVVTNSAAFTYFMAGALRRNISSDMLPQRFPLQLRTKSMGVFAPKLQELYPNQPMELHLWARQQPLLSCQPHALHGTLFGSVEAFVVLPNATRVPTFLLDIDANVTGKPTITRNRLGGTMKLTGGLLVPQVKRLETALKFGLWLFGVP
    

Molecular Weight18260.39 Da

Isoelectric Point (pI)10.09

Net Charge (pH 7.0)7.31

Net Charge (pH 7.4) 7.01

Charge Density (pH 7.0) 0.0443

GRAVY Index0.14

Hydrophobic Moment 0.52

Boman Index0.14

Instability Index45.39

Aliphatic Index 99.88

Aromaticity 0.0788

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6968.23

LogP -64.37

H-bond Donors 238.0

H-bond Acceptors 239.0

Rotatable Bonds 586.0

Heavy Atoms 1285.0

Ring Count 34.0

Amide Bonds 178.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0022193 VERIFIED: YES

Provenance & Taxonomy

OrganismChaetura pelagica [other]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria