Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length304 amino acids

Chemical FormulaC1546H2425N417O440S12

DescriptionStandard

        CQEGVATLQKDLPAITLPEFSGSYRVKVIGNVKYRFYSLNIRRFELLHSTIEPMPGQGLRVSISNALAEMTGRWELKKHWLNDDGSFELKVDGISISVGLKLGSDSTGRPTVTTLDCNTHISNVNIDISGKWDYSQYRQHIKHRLFSGWATGCDKSVCRPGPQGKLQHKAWKRMGLQKEASQFGISTYFFNTAGDVYYKSESLNFWIVDEMVPREVKIRLNTSSFQPFIPQMKKLYPNMAMKLKVSPSSVPSLSISPESISLTPSVEVLFKALRCWDLLARLAEGFPLPLLDHLELSNPVLQAH
    

Molecular Weight34278.10 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)8.43

Net Charge (pH 7.4) 7.67

Charge Density (pH 7.0) 0.0277

GRAVY Index-0.25

Hydrophobic Moment 0.75

Boman Index0.03

Instability Index41.71

Aliphatic Index 87.83

Aromaticity 0.0954

Extinction Coeff. Reduced 51910.00

Extinction Coeff. Oxidized 52160.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0424892 VERIFIED: NO

Provenance & Taxonomy

OrganismOphiophagus hannah [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence