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MYP_023972
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Basic Information
Dybowskin-2 (Frogs, amphibians, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
17 amino acids
C85H148N22O21S3
Standard
Sequence
FLIGMTQGLICLITRKC
Physicochemical Analysis
1910.41 Da
8.96
1.74
1.51
0.1023
1.21
0.46
0.34
14.61
137.65
0.0588
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
700.39
-4.03
27.0
26.0
65.0
131.0
1.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0153727 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
Brevinin
79015
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
11-17
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Staphylococcus aureus, Bacillus cereus, S. lactis and Escherichia coli
12.8-25.6 μM
MIC
PaperPurification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii
RECORD: Rec_0158272 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
30 μM
MIC
PMID17688900;17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17688900/
RECORD: Rec_0171123 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
60 μg/mL
MIC
PMID17688900;17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17688900/
RECORD: Rec_0173415 VERIFIED: YES
Provenance & Taxonomy
Rana dybowskii [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human red blood cells
PMID17698251 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17698251/
RECORD: Rec_0176417 VERIFIED: YES
Provenance & Taxonomy
Rana chensinensis [Animal]
brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
11-17
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
7.9 μM
MIC
PaperS.S. Kim et al. / Peptides 28 (2007) 1532-1539. Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii Evidence URLhttps://www.uniprot.org/uniprotkb/B8QZV5/entry
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