Peptide Database

Peptide NameSLAY-screened peptide P3272

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H168N42O25S

DescriptionStandard

        LMRWSVRTHRSHPSHKRGPH
    

Molecular Weight2462.80 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)5.11

Net Charge (pH 7.4) 4.70

Charge Density (pH 7.0) 0.2554

GRAVY Index-1.62

Hydrophobic Moment 0.66

Boman Index-0.47

Instability Index88.42

Aliphatic Index 34.00

Aromaticity 0.0500

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1083.69

LogP -12.16

H-bond Donors 41.0

H-bond Acceptors 35.0

Rotatable Bonds 77.0

Heavy Atoms 174.0

Ring Count 8.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0068661 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/