Peptide Database

Peptide NameThyrotropin Alfa

Function Ontology

Diagnostic Thyroid stimulation

Standard StatusStandard

Sequence Length204 amino acids

Chemical FormulaC1009H1554N268O299S27

DescriptionStandard

        APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSY
    

Molecular Weight23088.50 Da

Isoelectric Point (pI)8.30

Net Charge (pH 7.0)5.11

Net Charge (pH 7.4) 4.23

Charge Density (pH 7.0) 0.0250

GRAVY Index-0.23

Hydrophobic Moment 0.64

Boman Index0.01

Instability Index59.75

Aliphatic Index 59.26

Aromaticity 0.1127

Extinction Coeff. Reduced 22350.00

Extinction Coeff. Oxidized 23725.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0134202 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyThyrotropin

Tax ID9606

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Diagnostic Thyroid stimulation

Half-Life5 ± 10 h

PaperPubMed-linked source references: PMID:23389953; PMID:26622936; PMID:24040896; PMID:23406027; PMID:23014071; PMID:22551128; PMID:21607603; PMID:21404570 PMID23389953;26622936;24040896;23406027;23014071;22551128;21607603;21404570 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23389953/ PatentUS5840566