‹ ›
MYP_023817
← PREVIOUS NEXT → BACK
Basic Information
G154-177[B176A]
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
not Standard
24 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
KPPSKPNNDFHFEVFNFVPXSIAG
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0172678 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
stereochemistry not specified [Other]
Acetylation
Amidation
The 'B' at position 20 is S-acetamidomethyl cysteine.
Bio-Activity Profile
Antiviral Anti-RSV Entry inhibition
Respiratory syncytial virus(RSV) | HEp-2 cells
6 μM
IC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperAntiviral activity and structural characteristics of the nonglycosylated central subdomain of human respiratory syncytial virus attachment (G) glycoprotein. | Gorman JJ, McKimm-Breschkin JL, Norton RS, Barnham KJ. | J Biol Chem. 2001 Oct 19;276(42):38988-94. | DOI:10.1074/jbc.M106288200 | PMID:11487583 PMID11487583 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11487583/
RECORD: Rec_0421234 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
B: S-acetamidomethyl cysteine
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/