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MYP_023781
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Basic Information
Cycloviolacin O3
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Insecticidal/Pest control ▸ Insecticidal activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C134H217N37O40S6
Standard
Sequence
GIPCGESCVWIPCLTSAIGCSCKSKVCYRN
Physicochemical Analysis
3178.77 Da
8.33
1.70
1.40
0.0567
0.42
0.32
0.15
25.08
74.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1221.14
-14.26
49.0
48.0
99.0
217.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0242746 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Antiparasitic Nematocidal Anthelmintic Anti-Gram-negative
Pseudomonas aeruginosa
5 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7106003 | PubMed PMID 8000000 PMID2866976;7106003;8000000;28669767;10600;38000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0269841 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Antiparasitic Nematocidal Anthelmintic Anti-Gram-negative
Escherichia coli
10 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7106003 | PubMed PMID 8000000 PMID2866976;7106003;8000000;28669767;10600;38000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0273252 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0298749 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
97441
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Antifungal Antiparasitic Nematocidal Anthelmintic Anti-Gram-negative
Escherichia coli
5 μM
MIC
PaperPubMed PMID 2866976 | PubMed PMID 7106003 | PubMed PMID 8000000 PMID2866976;7106003;8000000;28669767;10600;38000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2866976/
RECORD: Rec_0314707 VERIFIED: NO
Provenance & Taxonomy
Viola odorata [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16872274 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16872274/
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