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MYP_023743
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Basic Information
Hominicin (Bacteriocin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
not Standard
21 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XTPATPFTPAITEITAAVIAX
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0053746 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus hominis [Bacterium]
Bacteriocin
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Dimethylation on Ile1
None
①The residue X at position 1 is DmIle (N1, N1-dimethyl-isoleucine).②The residues T at position 2, 5, 8 and 15 are dehydrobutyrine. ③The residue at position 21 is a distinct residue Dmp (N2, N2-dimethyl-1,2-propanediamine) rarely found from biosynthetic antimicrobial peptides
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
PMID20654578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20654578/
RECORD: Rec_0060311 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus hominis [Bacterium]
Bacteriocin
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Dimethylation on Ile1
None
①The residue X at position 1 is DmIle (N1, N1-dimethyl-isoleucine).②The residues T at position 2, 5, 8 and 15 are dehydrobutyrine. ③The residue at position 21 is a distinct residue Dmp (N2, N2-dimethyl-1,2-propanediamine) rarely found from biosynthetic antimicrobial peptides
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus (vancomycin-intermediate VISA) CCARM 3501
3.82 μg/mL
MIC
PMID20654578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20654578/
RECORD: Rec_0085379 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus hominis [Bacterium]
Bacteriocin
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Dimethylation on Ile1
None
①The residue X at position 1 is DmIle (N1, N1-dimethyl-isoleucine).②The residues T at position 2, 5, 8 and 15 are dehydrobutyrine. ③The residue at position 21 is a distinct residue Dmp (N2, N2-dimethyl-1,2-propanediamine) rarely found from biosynthetic antimicrobial peptides
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus ATCC 25923
0.06 μg/mL
MIC
PMID20654578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20654578/
RECORD: Rec_0375330 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus hominis [Bacterium]
Bacteriocin
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Dimethylation on Ile1
None
①The residue X at position 1 is DmIle (N1, N1-dimethyl-isoleucine).②The residues T at position 2, 5, 8 and 15 are dehydrobutyrine. ③The residue at position 21 is a distinct residue Dmp (N2, N2-dimethyl-1,2-propanediamine) rarely found from biosynthetic antimicrobial peptides
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus ATCC (MRSA) 11435
0.96 μg/mL
MIC
PMID20654578 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20654578/