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MYP_023735
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Basic Information
paracentrin 1 (SP1)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
11 amino acids
C56H94N14O18
Standard
Sequence
EVASFDKSKLK
Physicochemical Analysis
1251.43 Da
8.59
0.83
0.66
0.0759
-0.70
0.25
-0.23
-2.85
70.91
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
547.44
-5.08
19.0
19.0
45.0
88.0
1.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198249 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct based on Paracentrotus lividus [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
clude Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 29213, Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis RP62A, Staphylococcus aureus 100, Staphylococcus aureus 657,Staphylococcus aureus 700, Staphylococcus aureus 702, and Pseudomonas aeruginosa ATCC 15442
6.2-12.5 μg/mL
MIC
PaperParacentrin 1, a synthetic antimicrobial peptide from the sea-urchin Paracentrotus lividus, interferes with staphylococcal and Pseudomonas aeruginosa biofilm formation.
RECORD: Rec_0201425 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus aureus ATCC 25923
4.957, 2.479, 1.199, 0.56 μM
Safranin staining
RECORD: Rec_0249326 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0262665 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus epidermidis ATCC 35984
4.957, 2.479, 1.199, 0.56 μM
Safranin staining
RECORD: Rec_0306717 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperBaAMPs: the database of biofilm-active antimicrobial peptides PMID25760404 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25760404/
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