Peptide Database

Peptide NameCholecystokinin

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length94 amino acids

Chemical FormulaC456H725N145O143S3

DescriptionStandard

        QPVPPADSAVPGAQEEEAHRRQLRAVQKVDGESRAHLGALLARYIQQARKAPSGRVSMIKNLQSLDPSHRISDRDYMGWMDFGRRSAEEYEYTS
    

Molecular Weight10622.72 Da

Isoelectric Point (pI)8.32

Net Charge (pH 7.0)1.04

Net Charge (pH 7.4) 0.66

Charge Density (pH 7.0) 0.0111

GRAVY Index-0.90

Hydrophobic Moment 0.76

Boman Index-0.23

Instability Index73.76

Aliphatic Index 64.47

Aromaticity 0.0638

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4690.51

LogP -53.63

H-bond Donors 164.0

H-bond Acceptors 150.0

Rotatable Bonds 353.0

Heavy Atoms 747.0

Ring Count 16.0

Amide Bonds 101.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0085799 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyGastrin/cholecystokinin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsTyr76 Sulfotyrosine; Phe82 Amidation; Tyr90 Sulfotyrosine; Tyr92 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide

RECORD: Rec_0121648 VERIFIED: NO

Provenance & Taxonomy

OrganismSus scrofa [Animal]

FamilyCholecystokinin

Tax ID9823

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods76:Sulfotyrosine; 82:Phenylalanine amide; 90:Sulfotyrosine; 92:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0341135 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/