Peptide Database

Peptide NameTrefoil factor 1

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC297H452N84O93S7

DescriptionStandard

        QNQEETCAVIPRERINCGFPGVTAQQCKEKGCCFDDSVRGFPWCFRPLVIENQQEEECPF
    

Molecular Weight6911.73 Da

Isoelectric Point (pI)4.57

Net Charge (pH 7.0)-4.29

Net Charge (pH 7.4) -4.61

Charge Density (pH 7.0) -0.0714

GRAVY Index-0.60

Hydrophobic Moment 0.68

Boman Index-0.11

Instability Index64.22

Aliphatic Index 48.67

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5875.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2873.20

LogP -30.50

H-bond Donors 100.0

H-bond Acceptors 96.0

Rotatable Bonds 224.0

Heavy Atoms 481.0

Ring Count 12.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0002539 VERIFIED: YES

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyTrefoil factor

Tax ID10116

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermPyroglutamate

Disulfide7-33; 17-32; 27-44

Bio-Activity Profile

Function

Hormone Endocrine Growth regulation Development regulation

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour