Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length112 amino acids

Chemical FormulaC582H906N144O156S2

DescriptionStandard

        MWYSFLPCLLFLQLEANPGLKVRITQKGLDYGRKIGIELLKQRLLKESFPSWSGQESFSIVKVNYTISRFKVDAVDIPETFASFIAGTGVGLSVAHASVTISAGWKVEAWLL
    

Molecular Weight12480.42 Da

Isoelectric Point (pI)9.17

Net Charge (pH 7.0)2.59

Net Charge (pH 7.4) 2.28

Charge Density (pH 7.0) 0.0231

GRAVY Index0.27

Hydrophobic Moment 0.71

Boman Index0.19

Instability Index17.68

Aliphatic Index 107.05

Aromaticity 0.1250

Extinction Coeff. Reduced 26470.00

Extinction Coeff. Oxidized 26470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4784.47

LogP -34.59

H-bond Donors 169.0

H-bond Acceptors 162.0

Rotatable Bonds 410.0

Heavy Atoms 884.0

Ring Count 23.0

Amide Bonds 117.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0326398 VERIFIED: NO

Provenance & Taxonomy

OrganismColinus virginianus [Animal]

FamilyBPI

Tax ID9014

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence