Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2429H3780N630O687S20

DescriptionStandard

        MMARPHCVVVVLLLLAVVSGLEEGASNPGFVARITRKGLEYARQYGVAILKKELSTIELPDFSGSFKVSWIKIMSYEFYRLKIHDFELRNSDLRLCPRQGVRASLSNNYVSVSGNWKIKKAFFSFDGTFEMKVDDICISAFLNLGKDQSGRLTASMAHCNNSIGHISIDISGKLSWILNLFHERIENKFKNILEQKICEMVEKATTSRLEPYLQTLPVISMIDQVASIDYSLIGAPQVNSQVLDTPFKGEFFGQNGHSRAPFEAPPIRLPEKHDYMVYFAISEYVFNTASWVYHQAGYMNFTIQNQHISPDSPIHLHTSSFPALVPQLARMYPNMELELEMSPESAPLLMFTPGNVTLMPAIDVQAFALKPNSSDRKPLFQLRVQPRLGVTRASLSPHSKLKLELKHSNINFIDVELMEVILNYYALHTIYPSLNAKLEEGFPLPLPVDTYLNSSELQVHENFLLLLANLDY
    

Molecular Weight53441.10 Da

Isoelectric Point (pI)6.44

Net Charge (pH 7.0)-3.18

Net Charge (pH 7.4) -4.35

Charge Density (pH 7.0) -0.0067

GRAVY Index-0.05

Hydrophobic Moment 0.84

Boman Index0.10

Instability Index39.06

Aliphatic Index 97.29

Aromaticity 0.1017

Extinction Coeff. Reduced 48820.00

Extinction Coeff. Oxidized 49070.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0281829 VERIFIED: NO

Provenance & Taxonomy

OrganismCanis lupus familiaris [Animal]

FamilyBPI/LBP

Tax ID9615

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence