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MYP_023671
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Basic Information
Vibi E
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
30 amino acids
C132H210N34O40S6
Standard
Sequence
GIPCAESCVWIPCTVTALIGCGCSNKVCYN
Physicochemical Analysis
3105.67 Da
5.96
-0.30
-0.59
-0.0100
0.82
0.23
0.33
27.76
87.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1156.08
-12.70
45.0
46.0
93.0
212.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0291039 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 33.3%, E 6.7%, T 30.0%, C 30.0% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0319272 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
33090; 50557
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial; Cytotoxic
Human lymphoma cell line U-937 GTB
3.2 μM
IC50
PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0331413 VERIFIED: YES
Provenance & Taxonomy
Gloeospermum pauciflorum [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0368419 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Alpine violetViola biflora
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-21; 8-23; 13-28
Bio-Activity Profile
Anticancer; Cytotoxic
Human lymphoma cell line U-937 GTB
3.2 μM
IC50
PMID18191970;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0369415 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
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