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MYP_023671
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Basic Information
Vibi E
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
30 amino acids
C132H210N34O40S6
Standard
Sequence
GIPCAESCVWIPCTVTALIGCGCSNKVCYN
Physicochemical Analysis
3105.67 Da
5.96
-0.30
-0.59
-0.0100
0.82
0.23
0.33
27.76
87.67
0.0667
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1156.08
-12.70
45.0
46.0
93.0
212.0
5.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0119600 VERIFIED: NO
Provenance & Taxonomy
Viola biflora [Plant]
Cyclotide
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-21; 8-23; 13-28
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0144675 VERIFIED: NO
Provenance & Taxonomy
Viola biflora [Plant]
Cyclotide
214529
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
PaperPlant Antimicrobial Oligopeptides with Anticancer Properties as a Source of Biologically Active Peptides—An In Silico Study PMID41009751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41009751/
RECORD: Rec_0170819 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Defensin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-21; 8-23; 13-28
Bio-Activity Profile
Cytotoxic
Human lymphoma cell line U-937 GTB
3.2 μM
IC50
PaperPubMed PMID: 18191970 PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0242524 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]; Gloeospermum pauciflorum [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial
Human histiocytic lymphoma U-937/GTB
3.2±0.8 μM
IC50
PaperPubMed PMID 18191970 PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
RECORD: Rec_0272962 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Defensin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-21; 8-23; 13-28
Bio-Activity Profile
Cytotoxic
Human lymphoma cell line U-937 GTB
3.2 μM
IC50
PaperPubMed PMID: 18191970 PMID18191970 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18191970/
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