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MYP_023623
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Basic Information
Cyclic Gomesin [PYA1G, C2,6,11,15SeCys]
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
18 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GXRRLXYKQRXVTYXRGR
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0356521 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
ambiguous/non-standard residue notation [Modified]
None
None
X=Se-Cys
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: 32
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0371293 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
ambiguous/non-standard residue notation [Modified]
None
None
X=Se-Cys
Bio-Activity Profile
Antimicrobial Anticancer
MM96L
4.6±0.2 μM
CC50
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0375305 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
stapled cyclic peptide [Cyclic]
ambiguous/non-standard residue notation [Modified]
No specific N-terminal
No specific C-terminal
disulfide bond reported, sites not specified
The 'U' in sequence is SelenoCys
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Anticancer Cytotoxic
PBMCs
PaperRedesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. ACS Chem Biol. 2017 Sep 15;12(9):2324-2334. doi: 10.1021/acschembio.7b00459. PMID: 28741926. PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0379903 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
selenocysteine at 2,6,11,15
Bio-Activity Profile
Hemolytic
human erythrocytes
64 μM
Hemolysis
PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
RECORD: Rec_0413061 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
ambiguous/non-standard residue notation [Modified]
selenocysteine at 2,6,11,15
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 25923
16 μM
MIC
PMID28741926 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28741926/
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