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MYP_023613
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Basic Information
Tritrpticin [P5A] -AMD
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C94H130N28O14
Standard
Sequence
VRRFAWWWPFLRR
Physicochemical Analysis
1876.22 Da
12.00
3.73
3.52
0.2872
-0.53
0.47
-0.19
126.98
60.00
0.3846
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
698.70
0.15
28.0
18.0
53.0
136.0
9.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015777 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli
20 μg/mL
MBC
PMID24086578;29671805 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086578/
RECORD: Rec_0020630 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
8 μM
MIC
PMID24086578;29671805 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086578/
RECORD: Rec_0034496 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Jurkat T-cell leukemia
16.2 μM
IC50
PMID24086578;29671805 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086578/
RECORD: Rec_0046675 VERIFIED: YES
Provenance & Taxonomy
porcine cathelicidin peptide [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Jurkat
16.2 μM
IC50
PaperSelective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. Biochim Biophys Acta Biomembr. 2020 Aug 1;1862(8):183228. doi: 10.1016/j.bbamem.2020.183228. PMID: 32126228. PMID32126228 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32126228/
RECORD: Rec_0096048 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus
7 μg/mL
MBC
PMID24086578;29671805 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24086578/
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