Peptide Database

Peptide NameEK1V1

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC202H329N45O65S

DescriptionStandard

        SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELK
    

Molecular Weight4460.10 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-4.52

Net Charge (pH 7.4) -4.76

Charge Density (pH 7.0) -0.1223

GRAVY Index-0.53

Hydrophobic Moment 0.75

Boman Index-0.09

Instability Index20.09

Aliphatic Index 115.95

Aromaticity 0.0811

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1827.37

LogP -10.36

H-bond Donors 61.0

H-bond Acceptors 62.0

Rotatable Bonds 162.0

Heavy Atoms 313.0

Ring Count 3.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0403811 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermChol

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetHCoV-NL63:inhibition of pseudovirus infection in Huh-7 cells

Activity0.4872±0.0413 μM

MethodIC50

RECORD: Rec_0413871 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermChol

Other ModsChol

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2 D614G | protein-mediated cell; -cell

Activity0.2145±0.0202 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperSARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses. | Zhu Y, Yu D, Hu Y, Wu T, Chong H, He Y. | Signal Transduct Target Ther. 2021 Aug 3;6(1):294. | DOI:10.1038/s41392-021-00698-x | PMID:34344868 PMID34344868 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34344868/

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