Peptide Database

Peptide NameSLAY-screened peptide P3828

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC106H143N23O26S3

DescriptionStandard

        PWCSKYCWSCPLYNLGFSP
    

Molecular Weight2251.60 Da

Isoelectric Point (pI)8.29

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.82

Charge Density (pH 7.0) 0.0487

GRAVY Index-0.08

Hydrophobic Moment 0.24

Boman Index0.23

Instability Index70.84

Aliphatic Index 41.05

Aromaticity 0.2632

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 757.39

LogP -4.36

H-bond Donors 30.0

H-bond Acceptors 30.0

Rotatable Bonds 61.0

Heavy Atoms 158.0

Ring Count 10.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0292875 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/