Peptide Database

Peptide NameInsulin-like growth factor I-B

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC185H295N65O53S5

DescriptionStandard

        NNRRAHHRGIVDECCFQSCDFRRLEMYCAPAKPAKSAR
    

Molecular Weight4438.05 Da

Isoelectric Point (pI)9.25

Net Charge (pH 7.0)3.90

Net Charge (pH 7.4) 3.53

Charge Density (pH 7.0) 0.1026

GRAVY Index-0.87

Hydrophobic Moment 0.44

Boman Index-0.35

Instability Index81.23

Aliphatic Index 41.32

Aromaticity 0.0789

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1942.40

LogP -22.82

H-bond Donors 73.0

H-bond Acceptors 64.0

Rotatable Bonds 146.0

Heavy Atoms 308.0

Ring Count 7.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0166803 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyInsulin-like growth factor I

Tax ID8355

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide14-19

Bio-Activity Profile

Function

Hormone Endocrine Growth regulation Development regulation Receptor modulation

Targetintegrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling

Half-LifeMammalian: 1.4 hour; Yeast: 3 min; E. coli: >10 hour

RECORD: Rec_0354555 VERIFIED: YES