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MYP_023444
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Basic Information
AHB1
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Enzyme modulation ▸ Enzyme inhibition ▸ Binding inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
85 amino acids
C426H695N133O147S2
Standard
Sequence
DEDLEELERLYRKAEEVAKEAKDASRRGDDERAKEQMERAMRLFDQVFELAQELQEKQTDGNRQKATHLDKAVKEAADELYQRVR
Physicochemical Analysis
10096.01 Da
4.90
-6.11
-6.41
-0.0719
-1.42
0.84
-0.46
37.86
63.29
0.0471
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4704.63
-49.15
162.0
144.0
366.0
708.0
5.0
92.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0004699 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
Virus:SARS-CoV-2:Inhibition of infection in Vero E6 cells
0.035 μM
IC50
PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0206873 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV-2
PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0310215 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Binding inhibition
SARS-CoV-2 | E6 cells
0.035 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: >10 h
PaperDe novo design of picomolar SARS-CoV-2 miniprotein inhibitors. | Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D. | Science. 2020 Oct 23;370(6515):426-431. | DOI:10.1126/science.abd9909 | PMID:32907861 PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/
RECORD: Rec_0311956 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Miniprotein inhibitor
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus 2
0.035 μM
IC50
PaperDe novo design of picomolar SARS-CoV-2 miniprotein inhibitors PMID32907861 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32907861/