Peptide Database

Peptide NameSpiderine-2a (OtTx2a)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Insecticidal/Pest control ▸ Insecticidal activity

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length171 amino acids

Chemical FormulaC828H1321N221O254S12

DescriptionStandard

        MKFALVLLGVCAFYLVNATGDLETELEASELQELQEALDLIAETPLESLEAEELEEARKFKLPKINWGKLASKAKDVYKKGQKLAKNKNVKKALKYGKQLAENLAAGEVHEPGTPVGNNKCWAIGTRCTDDCDCCPEHHCHCPAKSWTFGLIPCSCQVTESDKVNKCPPAE
    

Molecular Weight18820.46 Da

Isoelectric Point (pI)5.67

Net Charge (pH 7.0)-4.22

Net Charge (pH 7.4) -4.87

Charge Density (pH 7.0) -0.0247

GRAVY Index-0.39

Hydrophobic Moment 0.70

Boman Index-0.02

Instability Index37.73

Aliphatic Index 80.53

Aromaticity 0.0585

Extinction Coeff. Reduced 20970.00

Extinction Coeff. Oxidized 21595.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7611.38

LogP -74.63

H-bond Donors 263.0

H-bond Acceptors 266.0

Rotatable Bonds 635.0

Heavy Atoms 1315.0

Ring Count 26.0

Amide Bonds 183.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0267989 VERIFIED: YES

Provenance & Taxonomy

OrganismOxyopes takobius [Animal]

FamilySpiderine; Cationic spiderine subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Cytolytic Toxin Cytotoxic Insecticidal Non-hemolytic

TargetNo Target Organism Found