MYP_023434
nepadutant
Neurological / Signaling
▸
Receptor modulation
▸
Agonist
Neurological / Signaling
▸
Receptor modulation
▸
Antagonist
Neurological / Signaling
▸
Signaling peptide
not Standard
6 amino acids
-
contains X representing unresolved or non-standard residue
NDWFXL
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0056524
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
GtoPdb peptide ligand
Structure & Mods
glycosylated bicyclic peptide [Cyclic]
modified/noncanonical amino-acid peptide [Modified]
Asn1 β-D-GlcNAc glycosylation; Dap5 noncanonical residue; Asp2-Dap5 lactam bridge
Bio-Activity Profile
Receptor antagonist
Signaling peptide
human tachykinin NK2 receptor; CHO cells
2.5±0.7 nM
Ki radioligand competition binding assay ([125I]-NKA)
RECORD: Rec_0432722
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Structure & Mods
glycosylated bicyclic peptide [Cyclic]
modified/noncanonical amino-acid peptide [Modified]
Asn1 β-D-GlcNAc glycosylation; Dap5 noncanonical residue; Asp2-Dap5 lactam bridge
Bio-Activity Profile
Receptor antagonist; Signaling peptide
rabbit isolated pulmonary artery tachykinin NK2 receptor response
8.6±0.07
pKB competitive functional antagonism assay