Peptide Database

Peptide NameHelicostatin-2a

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ Invertebrate inhibitory neuropeptide

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Invertebrate inhibitory neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC104H149N23O28

DescriptionStandard

        AYSYVSEYKRLPVYNFGL
    

Molecular Weight2169.43 Da

Isoelectric Point (pI)8.42

Net Charge (pH 7.0)0.79

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0441

GRAVY Index-0.20

Hydrophobic Moment 0.46

Boman Index0.10

Instability Index47.12

Aliphatic Index 81.11

Aromaticity 0.2778

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 838.92

LogP -4.65

H-bond Donors 30.0

H-bond Acceptors 29.0

Rotatable Bonds 65.0

Heavy Atoms 155.0

Ring Count 6.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0432713 VERIFIED: YES

Provenance & Taxonomy

OrganismHelicoverpa armigera [Animal]

FamilyAllatostatin/helicostatin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsC-terminal amidation

Bio-Activity Profile

Function

Neuropeptide; Myoinhibitory; Foregut peristalsis inhibitor

TargetHelicoverpa armigera larval crop/foregut musculature

Activity10^-7–10^-6 M

Methodin vitro crop/foregut peristalsis assay

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