Peptide Database

Peptide NameSLAY-screened peptide P2569

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC103H176N44O26S2

DescriptionStandard

        RSMRRRYVHLTRRALHNNAC
    

Molecular Weight2510.91 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)5.92

Net Charge (pH 7.4) 5.60

Charge Density (pH 7.0) 0.2962

GRAVY Index-1.17

Hydrophobic Moment 0.76

Boman Index-0.61

Instability Index143.66

Aliphatic Index 63.50

Aromaticity 0.0500

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1191.85

LogP -14.34

H-bond Donors 47.0

H-bond Acceptors 36.0

Rotatable Bonds 84.0

Heavy Atoms 175.0

Ring Count 3.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0415891 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/